Unlike alkylating agents, antitumor antibiotics:
1. are not given orally.
2. have severe adverse effects.
3. have no dose-limiting toxicities.
4. are not mitotic inhibitors.
Correct Answer: 1
Rationale 1: They must be given intravenously, or through direct instillation via a catheter into a body cavity or organ.
Rationale 2: Their adverse effects are similar.
Rationale 3: Their dose-limiting toxicities are similar.
Rationale 4: Their mechanisms of action are similar.
Global Rationale: Unlike the alkylating agents, however, all the antitumor antibiotics must be administered IV or through direct instillation via a catheter into a body cavity or organ. Adverse effects, dose-limiting toxicities, and mechanisms of action are similar.
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