A client with bipolar disorder is prescribed lithium. The nurse is reviewing the client's medication history for drugs that could interact with lithium
The nurse would monitor the client's serum lithium concentrations closely for toxicity if the client's medication history included which of the following? Select all that apply.
A) Captopril
B) Fluoxetine
C) Hydrochlorothiazide
D) Mannitol
E) Isosorbide
Ans: A, B, C
Medications such as captopril, fluoxetine, and hydrochlorothiazide increase serum lithium concentration, placing the client at increased risk for lithium toxicity. Mannitol and isosorbide increase renal excretion of lithium, thus decreasing lithium concentration.
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