Drug molecules that are bound to plasma proteins are:
a. ready for elimination. c. pharmacologically active.
b. pharmacologically inactive. d. biotransformed.
ANS: B
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A Incorrect: They have not been distributed to their site of action.
B Correct: Protein-bound drugs are unable to elicit a pharmacological effect until the active drug level falls.
C Incorrect: Once the drug is released from the plasma protein, it is pharmacologically active.
D Incorrect: Protein-binding occurs during distribution.
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