A nurse is teaching a nursing student who wants to know how aspirin and nonaspirin first-generation NSAIDs differ. Which statement by the student indicates a need for further teaching?
a. "Unlike aspirin, first-generation NSAIDs cause reversible inhibition of cyclooxygenase."
b. "NSAIDs do not increase the risk of MI and stroke; however, unlike ASA, they do not provide protective benefits against those conditions."
c. "Unlike aspirin, first-generation NSAIDs do not carry a risk of hypersensitivity reactions."
d. "Unlike aspirin, first-generation NSAIDs cause little or no suppression of platelet aggregation."
ANS: C
Nonaspirin first-generation NSAIDs carry a risk of hypersensitivity reactions similar to the risk posed by ASA. These agents cause reversible COX inhibition, whereas ASA causes irreversible COX inhibition. NSAIDs do not provide protective benefits for MI or stroke, as does ASA. Nonaspirin first-generation NSAIDs do cause suppression of platelet aggregation, but the suppression is reversible.
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