Describe the effects of excess alcohol intake on folate utilization

Question

What will be an ideal response?

Answer 1

Chronic alcohol abuse not only displaces nutrients from the diet, but it also interferes with the body's metabolism of nutrients. Most dramatic is alcohol's effect on the B vitamin folate. The liver loses its ability to retain folate, and the kidneys increase their excretion of it. Alcohol abuse creates a folate deficiency that devastates digestive system function. The small intestine normally releases and retrieves folate continuously, but it becomes damaged by folate deficiency and alcohol toxicity, so it fails to retrieve its own folate and misses any that may trickle in from food as well. Alcohol also interferes with the action of folate in converting the amino acid homocysteine to methionine. The result is an excess of homocysteine, which has been linked to heart disease, and an inadequate supply of methionine, which slows the production of new cells, especially the rapidly dividing cells of the intestine and the blood. The combination of poor folate status and alcohol consumption has also been implicated in promoting colorectal cancer.