Explain the meaning of the phrase "fat burns in the flame of carbohydrates" in regards to how carbohydrates help in fat metabolism.
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In addition to its role in energy production, the citric acid cycle provides compounds that leave the cycle and are used for other pathways. This results in a slowing of the cycle, as eventually not enough oxaloacetate is formed to combine with the acetyl-CoA entering the cycle. Cells are able to compensate for this by synthesizing additional oxaloacetate. One potential source of this additional oxaloacetate is pyruvate (Fig. 9-14). Thus, as fatty acids create acetyl-CoA, carbohydrates (e.g., glucose) are needed to keep the concentration of pyruvate high enough to resupply oxaloacetate to the citric acid cycle. Overall, the entire pathway for fatty acid oxidation works better when carbohydrate is available.
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