Which is a true statement about medications taken by individuals with diabetes mellitus?
a. Sitagliptin (Januvia) is indicated to treat type 1 diabetes mellitus.
b. Nateglinide (Starlix) acts by increasing the secretion of insulin.
c. Metformin (Glucophage) acts by increasing insulin secretion.
d. Rosiglitazone (Avandia) acts by decreasing glucose absorption.
B
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A Incorrect. Use of sitagliptin (Januvia), a dipeptidyl-peptidase-4 inhibitor, is in-dicated for type 2 diabetes mellitus and acts by improving glucose-dependent insulin synthesis, lowering glucagon secretion, and slowing gastric emptying.
B Correct. Meglitinides such as nateglinide (Starlix) act by helping the pancreas to release insulin.
C Incorrect. Metformin (Glucophage) acts by decreasing the release of glucose from the liver.
D Incorrect. Thiazolidinediones such as rosiglitazone (Avandia) act by enhancing insulin sensitivity with hepatic glucose metabolism and by enhancing insulin receptor kinase activity and phosphorylation.
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