The duration of a client's response to an antidepressant medication is shorter than normal. Which genetic finding could account for this abnormal response?
1. The client lacks an enzyme to metabolize the drug.
2. The enzyme that metabolizes the drug is only partially functional.
3. A gene duplication may exist.
4. Genes likely have no effect on this particular class of drugs.
3
Rationale 1: Lack of an enzyme to metabolize the drug would result in the drug remaining in the client's system for an extended period and its effects lasting longer than normal, possibly resulting in toxicity.
Rationale 2: If this enzyme is only partially functional, the drug will remain in the client's system longer than normal.
Rationale 3: Gene duplication may cause the metabolism of these drugs to increase, thereby clearing them from the client's system more quickly. This would result in a decreased length of effect.
Rationale 4: Pharmacogenetics is the study of how genes influence the metabolism of drugs. Genetic variations that produce differences in protein expression affect the structure of receptors, transporters, and enzymes necessary for drug activity, metabolism, and clearance.
You might also like to view...
The nurse knows that the dehydration associated with diabetic ketoacidosis results from
a. increased serum osmolality and urea. b. decreased serum osmolality and hyperglycemia. c. ketones and potassium shifts. d. acute renal failure.
The nurse explains that a therapeutic relationship differs from a social relationship in that the therapeutic relationship:
a. has no boundaries. b. is goal directed. c. meets the needs of each person in the rela-tionship. d. extends past the hospitalization period.
What is the highest total dosage for the drug administration period for this patient?
What will be an ideal response?
A client is asking the clinic nurse for suggestions to lower her risk for developing cancer. Which of the following is a possible suggestion?
A) Exercise at least 175 minutes each week. B) Consume a healthy diet with emphasis on plant food. C) Maintain a BMI of 18. D) Consume a healthy diet with emphasis on animal food.